Literature summary extracted from

Hagemann, S.; Guenther, T.; Dennemaerker, J.; Lohmueller, T.; Broemme, D.; Schuele, R.; Peters, C.; Reinheckel, T.
The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles (2004), Eur. J. Cell Biol., 83, 775-780.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.22.43	transgenic expression in cathepsin L-deficient mice, phylogenetic tree	Homo sapiens

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.4.22.43	additional information	the enzyme can complement cathepsin L-deficient mice by expression of cathepsin V in epidermis and hair follicles, the mutant mice suffer from a complex skin phenotype consisting of hair loss and epidermal hyperplasia with hyperproliferation of basal epidermal keratinocytes, acanthosis, and hyperkeratosis, overview	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.43	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.43	cornea	-	Homo sapiens	-
3.4.22.43	epidermis	-	Homo sapiens	-
3.4.22.43	additional information	selective, tissue-specific expression	Homo sapiens	-
3.4.22.43	testis	-	Homo sapiens	-
3.4.22.43	thymus	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.22.43	cathepsin L2	-	Homo sapiens

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Release 2023.1 (January 2023)